blood type b and covid vaccine side effects blood type b and covid vaccine side effects

To date, coronavirus disease 2019 (COVID-19), a newly emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 600 million people worldwide and killed over 6 million people (1, 2). afficher des publicits et des contenus personnaliss en fonction de vos profils de centres dintrt; mesurer lefficacit des publicits et contenus personnaliss; et. Participants with blood type A had lower levels of neutralizing antibodies than those with blood type B during 114 days after vaccination (least-square mean difference = 15.8, 95% CI 11.025.2; p = 0.044) (Table S2). It usually occurs soon after vaccination, and can be treated with epinephrine (as in an EpiPen). Congestion/runny nose. As with all vaccines, side effects may occur after getting the COVID-19 vaccine. It varies from person to person, but how dramatic the initial response is does not necessarily relate to the long-term response. Science-based COVID-19 vaccine development. We dont know why people with Type O might possibly be more protectedbut there are a lot of theories. Based on the duration after vaccination of the participants, we divided the duration after vaccination of the participants into eight groups: 114, 1530, 3060, 6190, 91120, 121150,151180, and 181240 days. The levels of IFN- and CD4+ T-lymphocytes were not altered in the participants for 240 days after vaccination, whereas the levels of neutralizing antibodies, B-lymphocytes, and IL-6 decreased with increasing time after vaccination. That link was established pretty early on in the pandemic and scientists didn't let it go. In cases of severe adverse events, the investigator contacted the participant, and the intensity of adverse events was graded according to the adverse events severity scale as follows: 1, mild; 2, moderate; 3, severe; or 4, life-threatening. Lancet (2021) 398:12130. Other neurological side effects occur in a much lower frequency. I don't think that having Type A or Type B is the problemit's just that they don't have Type O," says Mark Udden, MD, professor of hematology and oncology at Baylor College of Medicine in Houston. Diarrhea. Factors that influence the concentration of neutralizing antibodies and cellular responses were analyzed using a multivariate linear regression model, which could be set on one of the classified variances as a reference to calculate the B value (18). The .gov means its official. Based on their data, the Novavax vaccine has a significantly lower rate of side effects compared to the Pfizer-BioNTech and Moderna vaccines. All Rights Reserved. Therefore, we speculate that the concentration of neutralizing antibodies may be increased more rapidly after the third or fourth dose of booster. The blood type-infection connection is not unique to the coronavirus. Epub 2021 May 25. In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. The results were notable: Adjusting for demographics and co-morbidities, the risk for a COVID-19 diagnosis was 12 percent lower for people with type O blood and the risk for severe COVID-19 or death was 13 percent lower, compared to those with A, AB, or B blood types. Cytokine levels and lymphocyte subset counts were measured using flow cytometry (Beamcyte-1026; Changzhou Beamdiag Co., Ltd., Changzhou, China). 2023;47(1):5. doi: 10.1186/s42269-023-00981-7. Bethesda, MD 20894, Web Policies Previous research has found that people with A blood types are more at risk. 2022 Dec 22;78:100157. doi: 10.1016/j.clinsp.2022.100157. Molly Walker is deputy managing editor and covers infectious diseases for MedPage Today. COVID-19 vaccine guidelines was numerous in quantity but many lack transparent reporting of methodological practices. Reactogenicity analysis results are presented as percentage of participants. Many people have reported side effects, such as headache, fatigue, and soreness at the injection site, that are generally mild to moderate and go away within a few days. These include anaphylaxis, a severe reaction . Many COVID-19 . Costa Clemens SA, Weckx L, Clemens R, Almeida Mendes AV, Ramos Souza A, Silveira MBV, et al. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). doi:10.1016/S0140-6736(22)00094-0, 7. Therefore, the objective of this study was to evaluate the cellular immune responses and neutralizing antibody kinetics of homologous and heterologous administrations of an inactivated coronavirus disease 2019 (COVID-19) vaccine 240 days after the second vaccination. Vaccine (2021) 39:114856. The couple will likely attend the big event. if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { COVID-19 vaccine coverage, concerns, and preferences among Chinese ICU clinicians: A nationwide online survey. BM, GC, and ZW contributed to the collection and interpretation of the laboratory and clinical data. doi:10.2144/fsoa-2021-0045, 18. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). All rights reserved. They looked at patients from March 3 to Nov. 2, 2020 who were tested for SARS-CoV-2 and had a recorded blood type, comparing positive versus negative tests, hospitalized versus non-hospitalized patients and ICU versus non-ICU patients. The most common adverse effect was fatigue (n = 4), followed by fever (n = 2), injection site pain (n = 4), malaise (n = 4), rash (n = 4), and pruritus (n = 3). In all cases, the immune system creates antibodies that activate platelets in the bloodstream, he said. Researchers have been talking about blood type and COVID-19 susceptibility for months. According to Public Health England, most side-effects from two Covid vaccines - Pfizer/BioNTech and Oxford/AstraZeneca - are mild and short-lived. Unexplained deaths. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. J Neuroimmunol. It's becoming more common in people under 55. Unfortunately, this is a much more rare blood type. Please enable it to take advantage of the complete set of features! Table1 Baseline characteristics of the study participants (N = 595). This is why some vaccines require a brief observation period after your shot. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. FOIA -, Wang MW, Wen W, Wang N, et al. Along with its needed effects, sars-cov-2 (covid-19) mrna-1273 vaccine (the active ingredient contained in Moderna COVID-19 Vaccine) may cause some unwanted effects. Fatigue, headaches, muscle and joint aches and fever are all potential side effects as well. Latest research and advice on side effects and allergic reactions related to COVID-19 vaccines. Received: 25 November 2022; Accepted: 20 February 2023;Published: 03 March 2023. At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. 2021;144(1):109110. METHODOLOGY A cross-sectional study was carried out, in which . . J Med Virol (2022) 94:411524. Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and variants of concern. Acute disseminated encephalomyelitis following the COVID-19 vaccine Ad26.COV2.S, a case report. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. The discovery of Type Os protective effect is crucial to building an understanding of how the virus works. And for more on the state of the pandemic, check out These 2 Places Could Be Closing Soon, White House Official Warns. Methods: This prospective, multicenter, observational, longitudinal study involved 595 participants with a negative SARS-CoV-2 polymerase chain reaction result who were serologically tested and followed for 8 months after vaccination. Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. All studies so far have only looked at blood type in connection to symptomatic cases of coronavirus, Dr. Aronoff points out. Front. Table3 Factors associated with the levels of interferon-gamma after the administration of the Chinese inactivated COVID-19 vaccine. Lau YL, Fan Leung T, Sirvan Cetin B, Cagri Dinleyici E, Huang LM, Halperin SA, et al. Front Neurol. They looked at both how likely a patient was to contract COVID-19, and how likely they were to become seriously ill (or even die) from it if they did. You've read a lot about what puts you at an increased risk of having a severe case of COVID-19, from smoking to carrying around extra weight to being over a certain age. A few side effects are serious, but rare. Although the statistical analysis controlled for potential confounders, we included variables that showed significant associations with humoral and cellular responses in the mixed model. ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. MeSH In contrast, people with blood type O appear to have about a 50 percent reduced risk of severe COVID-19. Online ahead of print. Table6 Factors associated with IL-6 level after the administration of the Chinese COVID-19 inactivated vaccine. A review of neurological side effects of COVID-19 vaccination. Unfolding the determinants of COVID-19 vaccine acceptance in China. JAMA (2021) 326:204354. Between June 19, 2021 and April 30, 2022, healthy or clinically stable adults (aged 1880 years) who had received two doses of the inactivated COVID-19 vaccine between 3 and 8 weeks (2156 days) before the screening visit were recruited. Wong LP, Alias H, Siaw YL, Muslimin M, Lai LL, Lin Y, et al. This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. If youre older or have an underlying disease like cancer, diabetes, or heart disease, youre more likely to develop a severe case of coronavirus, Dr. Udden adds. This article is part of Harvard Medical School's continuing coverage of medicine, biomedical research, medical education and policy related to the SARS-CoV-2 pandemic and the disease COVID-19. Based on their age, we divided the participants into three groups, namely, 1830, 3150, and >50 years old. COVID vaccines and safety: what the research says. Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). Are the Vaccines Safe? The concentration kinetics of IgG neutralizing antibodies were evaluated against the RBD for all study participants at least once during the 8-month timeframe and at least four times for 119 participants (20%). J Clin Epidemiol (2022) 144:16372. Most side effects are mild and normally last only a day or two. Follow-up visits were scheduled on days 130 to measure vital signs, review any solicited and unsolicited adverse events, and update medical and medication records. } Prospective cohort of Chinese individuals immunized with the inactivated vaccine and serological assays. HHS Vulnerability Disclosure, Help Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. In contrast, we observed a decrease in the B-lymphocyte count and IL-6 level on days 1 to 240 in participants stimulated with the SARS-CoV-2 S antigen (B = 0.004, 95% CI 0.005 to 0.003; p = 0.008 and B = 0.004, 95% CI 0.006 to 0.002, p = 0.001, respectively; Tables5, 6; Figures3A, G).