Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. However, if handling bulk powders, observance of appropriate safeguards is recommended. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. X]s
;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. INCI. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Dyvo5bp#bR W7~IF C"
d6zLz~!#>@HO}sx;hm>> Truly distinctive drug delivery solutions. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. 130. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[
No. 6 q86@on$^X_HuH;3` To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. : 5. : 160182. Trademarks: Avicel PH-102. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Buy Chemicals. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Regulatory Information In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. . Avicel Microcrystalline Cellulose: Chemical Identifiers. ). (Microcrystalline Cellulose Market Pr. We respect your privacy FMC Privacy Policy. EMCOCEL 90 M. 130. CAS #: 9004-34-6 . In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. <
gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. ( Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. No. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Manufacturer: FMC BioPolymer. <>
The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. <>
Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. gac74
[#B6`Wnw7 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W It is also inert and biocompatible. We know that our customers need to provide reliable and consistent products to their patients. No. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. common form is used in vitamin supplements or tablets. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Browse Avicel PH-101 and related products at MilliporeSigma. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * There may be more fiber in your food than you realized. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. HMo@9, U Q!R/1*;` This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. /Type/Page
MATERIAL SAFETY DATA SHEET. This Microcrystalline Cellulose . POLYOX resins are nonionic polyethylene oxide solubility polymers. Microcrystalline Cellulose (MCC) Manufacturing Industry. zW0}
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3Fz. q9;v80 Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Learn about FMC's differentiated biologically-based crop solutions. : CL-611NF Date Approved: 01/13/2010. <>
Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. MCC helps in the formation of spheres because of its . Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Microcrystalline Cellulose / Avicel PH-102. } !1AQa"q2#BR$3br Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. cas:9000-11-7 msds Carboxymethyl cellulose. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@
qaj/QU<5OrVMfl{pL? No. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. EINECS #: 232-674-9 1.7. Medium size standard MCC grade, suited for the majority of directly compressible actives. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. . G2W4de=u183KGH{ vQ#4:1\wc Product Name: Microcrystalline Cellulose E460 1.2. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Are you sure you want to delete your template? Aqueous suspensions of microcrystalline cellulose have . We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Instead, they obtained a stable colloidal suspension. endobj
Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. X\o^ This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. It is hygroscopic and insoluble in water. }o]X4]. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Request media, explore upcoming events and read our latest updates. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Cellulose microcrystalline. It is a white, free-flowing powder. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. PDF (4.11 mb) Footer menu 1. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. These, in turn, are assembled into fibrils in the cell wall. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM
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WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Some substance identifiers may have been claimed confidential, or may . $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Production of Pharmaceutical Grade Microcrystalline Cellulose. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. endobj
This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. MATERIAL SAFETY DATA SHEET. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. 102331. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . High performance lubricant that brings more to the tablet. Microcrystalline Cellulose. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. MSDS Ref. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. %PDF-1.3 ( Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Thus, Avicel contributes no or very few calories to the food system. lH5JWy}DgKRR"Fs pH 6.0 to 8.0 . Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. (1962). 2008-2023 ChemPoint. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Manufactured by: China . 4 0 obj
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Watch Now. By producing Avicel . Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements.
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